Magazine: Modeling protein dependency networks using CoCoA
FREE CONTENT FEATURE
In an interdisciplinary effort to model protein dependency networks, biologists measure signals from certain proteins within cells over a given interval of time. Using this time series data, the goal is to deduce protein dependency relationships. The mathematical challenges is to statistically measure correlations between given proteins over time in order to conjecture probable relationships. Biologists can then consider these relationships with more scrutiny, in order to confirm their conjectures. One algorithm for finding such relationships makes use of interpolation of the data to produce next-state functions for each protein and the Deegan-Packel Index of Power voting method to measure the strength of correlations between pairs of proteins.
Modeling protein dependency networks using CoCoA
Full text also available in the ACM Digital Library as PDF | HTML | Digital Edition